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There has been steady improvement in the proportion of diabetic patients achieving recommended levels of A1C, blood pressure, and LDL cholesterol in the last 10 years, both in primary care settings and in endocrinology practices.

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11 In females with mildtomoderate disease, IV regimens appear to have equal efficacy to oral regimens.

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The changes in lipid endpoints after an additional 48 weeks of treatment with ezetimibe coadministered with fenofibrate or with fenofibrate alone were consistent with the 12-week data displayed above.

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Given the inability of statins to reduce plant sterol levels and the incomplete lowering of sterol levels with other treatments such as low-sterol diets and bile-acid binding resins, ezetimibe has emerged as an effective alternative strategy.

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FDA is requiring changes to the simvastatin label to add new contraindications (should not be used with certain medications) and dose limitations for using simvastatin with certain medicines.

European Atherosclerosis Society, the Japan Atherosclerosis Society, the National Institute for Health and Clinical Excellence, and the International Atherosclerosis Society recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone.

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Berberine has been implicated in attenuating increases of PCSK9 (a protein that suppresses expression of the LDL receptor) which may disconnect the side effect of high cholesterol from conditions that induce PCSK9 activity; this includes inflammation (leading to it being referred to as 'the next statin' by some ) and statin drugs, where the induction of PCSK9 appears to limit the statin's own ability to reduce cholesterol.

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Medications in these classes may be used to treat alternate conditions beyond hypertension.

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