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11 In females with mildtomoderate disease, IV regimens appear to have equal efficacy to oral regimens.

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Given the inability of statins to reduce plant sterol levels and the incomplete lowering of sterol levels with other treatments such as low-sterol diets and bile-acid binding resins, ezetimibe has emerged as an effective alternative strategy.

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FDA is requiring changes to the simvastatin label to add new contraindications (should not be used with certain medications) and dose limitations for using simvastatin with certain medicines.

European Atherosclerosis Society, the Japan Atherosclerosis Society, the National Institute for Health and Clinical Excellence, and the International Atherosclerosis Society recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone.

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Berberine has been implicated in attenuating increases of PCSK9 (a protein that suppresses expression of the LDL receptor) which may disconnect the side effect of high cholesterol from conditions that induce PCSK9 activity; this includes inflammation (leading to it being referred to as 'the next statin' by some ) and statin drugs, where the induction of PCSK9 appears to limit the statin's own ability to reduce cholesterol.

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