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Hypertension is a common comorbidity of diabetes, affecting the majority of patients, with prevalence depending on type of diabetes, age, obesity, and ethnicity.
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There has been steady improvement in the proportion of diabetic patients achieving recommended levels of A1C, blood pressure, and LDL cholesterol in the last 10 years, both in primary care settings and in endocrinology practices.
The C max value of ezetimibe was increased by 38% with consumption of high-fat meals.
Berberine has a high potential to interact with a medications, and some interactions may be serious.
11 In females with mildtomoderate disease, IV regimens appear to have equal efficacy to oral regimens.
Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment.
When a silent myocardial infarction was detected on the basis of serial comparison of ECGs, the event was considered to have occurred midway between the first diagnostic ECG and the previous ECG.
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Berberine has been shown to have Muscarinic (M2) acetylcholine receptor agonist activities, which has been noted in cultured rat cardiomyocytes where antagonists of the Muscarinic receptor but not beta-blockers abolished the benefits on heart tissue contractility.
Cost effectiveness of a general practice chronic disease management plan for coronary heart disease in Australia.
One purpose of this letter is to demand that the FDA immediately convene a meeting on Viagra of its cardiovascular advisory committee--a committee which was completely bypassed during the dangerously-rushed six months between the submission of the new drug application for Viagra to the FDA and its approval.
The changes in lipid endpoints after an additional 48 weeks of treatment with ezetimibe coadministered with fenofibrate or with fenofibrate alone were consistent with the 12-week data displayed above.
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Furthermore, a significant treatment effect was seen in the subgroup without multiple risk factors and the subgroup without preexisting vascular disease.
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This interest is generated especially because of the continuing exploration of niacin's "pleiotropic" mechanisms of action and its potential in the "cross-talk" between metabolic and inflammatory pathways.
Equipping patients with an algorithm for self-titration of insulin doses based on SMBG results improves glycemic control in type 2 diabetic patients initiating insulin ().
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Given the inability of statins to reduce plant sterol levels and the incomplete lowering of sterol levels with other treatments such as low-sterol diets and bile-acid binding resins, ezetimibe has emerged as an effective alternative strategy.
Each drug has unique properties that when used in combination have proven to be an effective treatment against high cholesterol.
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FDA is requiring changes to the simvastatin label to add new contraindications (should not be used with certain medications) and dose limitations for using simvastatin with certain medicines.
European Atherosclerosis Society, the Japan Atherosclerosis Society, the National Institute for Health and Clinical Excellence, and the International Atherosclerosis Society recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone.
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Representative images of cultured EPCs in patient with CHF before and after simvastatin treatment (D) and in patient with CHF before and after ezetimibe treatment (E) are shown.
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The primary outcome was a composite of major cardiovascular events, including death from cardiovascular causes, aortic-valve replacement, nonfatal myocardial infarction, hospitalization for unstable angina pectoris, heart failure, coronary-artery bypass grafting, percutaneous coronary intervention, and nonhemorrhagic stroke.
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The lack of any effect on the progression of aortic stenosis as seen on echocardiography supports the conclusion that the lack of effect on clinical valve-related events was real and not due to a lack of statistical power.
Followups continued through September 2007.
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Berberine has been implicated in attenuating increases of PCSK9 (a protein that suppresses expression of the LDL receptor) which may disconnect the side effect of high cholesterol from conditions that induce PCSK9 activity; this includes inflammation (leading to it being referred to as 'the next statin' by some ) and statin drugs, where the induction of PCSK9 appears to limit the statin's own ability to reduce cholesterol.
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Medications in these classes may be used to treat alternate conditions beyond hypertension.
The results are due to be released in 2014 and are hoped to give important information on the effect and safety profile of -C lowering with combination therapy.
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